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The lethal dose in humans would be approximately 21,000mg for a 70kg person, making the 1-3mg daily doses used in typical protocols extremely safe from a toxicity standpoint

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With basic formulations, injectable has higher bioavailability (80-95% vs 40-60% for nasal, less for standard oral)

B vitamin status directly affects nerve health

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Start with a fresh vial and mark the discard date 28 days out