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Bowers CY, Momany FA, Reynolds GA, Hong A On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone

Previous studies have shown that GPER activation can upregulate the expression of Runx2 and osteocalcin, both of which are genes related to bone formation [110, 144]

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In rodent knockout models where beta-3 adrenergic receptors were removed, the lipolytic response to AOD 9604 was eliminated, confirming the receptor-specific mechanism