For context within the broader class, semaglutide was studied in STEP (NEJM 2021)
This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements
To boost the efficacy of your supplements, incorporate nitrate-rich foods like beets and leafy greens into your diet
Researchers have also discovered that it plays a role in preventing coronary artery diseases (atherosclerosis)
It is believed to work through several pathways: Blocking voltage-dependent sodium channels , reducing neuronal excitability Enhancing GABA (gamma-aminobutyric acid) activity , an inhibitory neurotransmitter Antagonising glutamate receptors , further dampening excitatory neurotransmission Inhibiting carbonic anhydrase enzymes , though the clinical significance of this effect varies Topiramate is taken orally, typically once or twice daily
Ensuring adequate calcium intake is vital, especially for those on GLP-1 medications