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Radiologically, intramedullary melanotic neoplasms exhibit hyperintensity on T1-weighted MRI and hypointensity on T2-weighted MRI due to the paramagnetic effect of melanin

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NONSTEROIDAL ANTI-INFLAMMATORY DRUGS MECHANISM OF ACTION The nonsteroidal anti-inflammatory drugs comprise a large family of weak acidic drugs whose pharmacological effects result primarily from the inhibition of cyclooxygenase (COX) , an enzyme that catalyzes the first step in the synthesis of prostaglandins from arachidonic acid and other precursor fatty acids (see Chapter 26)