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After 28 days, aggregates accumulate to the point where biological activity drops measurably, and immunogenic risk from aggregated proteins increases

Room temperature storage is acceptable only for very short periods

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ElSayed NA, Aleppo G, Aroda VR et al (2023) 9

Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome