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We recommend future research directions to determine when to start with SL, IM, or oral vitamin B12 in different situations

Absorption can also be inhibited by poorly functioning kidneys, cigarette smoke, nitrous oxide used for anaesthesia, heating food in a microwave or cooker and some medications, including Metformin (for diabetes), anticonvulsants and proton pump inhibitors (PPIs)

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Regulation of and Challenges in Targeting NAD(+) Metabolism. Nature Reviews