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If a patient is suspected to be experiencing OIH, carefully consider appropriately decreasing the dose of the current opioid analgesic, or opioid rotation (safely switching the patient to a different opioid moiety) [see DOSAGE AND ADMINISTRATION, WARNINGS]

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While significant advances have been made in ferroptosis research in OSCC, another novel metal ion-dependent form of cell deathcuproptosishas increasingly demonstrated its critical role in OSCC in recent years