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I get a lot of pushback on that from physicians saying, Why would you want to burden a patient with that knowledge? I welcome that debate because it opens a discussion: Do you or do you not believe that this a deterministic gene

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Even in the case of NTDT, where iron absorption rates exceed normal levels (12 mg/day), the lack of extensive transfusion can contribute to 35 mg/day of iron absorption, representing 15 g of iron overload in a year

Many proteins which underwent dysregulated abundance under both basal and ROS conditions were reductases, oxidases, stress response proteins and enzymes with oxidising products (Supplementary Tables S3 and S4)

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Vitamin B12 is poorly absorbed in pill form, and not much reaches the bloodstream