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In our animal study, we intentionally excluded drugs with known adverse effects, specifically four chemotherapeutic agents (entinostat, tucidinostat, enzastaurin, and abemaciclib) known for their toxicities

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doi: 10.1016/j.carbpol.2015.08.051

Second, and more importantly, it can prevent complete bladder emptying

Klotho: The Longevity Factor Klotho is a transmembrane protein that declines dramatically with aging and has emerged as one of the most compelling therapeutic targets for cognitive enhancement

None of these differences reached statistical significance, though the studies were not powered specifically for this outcome