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The term oxidative stress, first introduced by Helmut Sies in the late 1980s ( In IBD, evidence suggests that oxidative stress plays a crucial role in the onset and progression of the disease ( Over the past decades, extensive research has been conducted to understand the mechanisms underlying oxidative stress in IBD

Immunoblot with antibody against lipoic acid in the indicated Jurkat SLC25A39 knockout cells expressing a vector control or SLC25A39 cDNA transduced with the indicated sgRNA

DOI: 10.3389/fimmu.2017.01320

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Topical GHK-Cu peptide creams, serums, and lotions are likely the most accessible products for overall skin health