Diabetes and high blood pressure are the two most common causes of kidney disease, which if not detected and treated early can lead to kidney failure end-stage kidney disease requiring dialysis or a kidney transplant
Studies have shown that inhibiting VEGF-dependent angiogenesis in the TME with axitinib can relieve T cell hypoxia and limit the exposure of tumor-infiltrating T cells to metabolic stress, significantly improving the efficacy of immunotherapy
The challenge for these companies is maintaining brand identity while embracing pharmaceutical interventions that might seem at odds with their original philosophy
doi: 10.3389/fendo.2023.1132004 Received 26 December 2022 Accepted 29 May 2023 Published 26 June 2023 Volume 14 - 2023 Edited by Miaofen Hu, Tufts Medical Center, United States Reviewed by Anapaula Sommer Vinagre, Federal University of Rio Grande do Sul, Brazil
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