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By inhibiting NNMT, 5-Amino-1MQ is theorized to spare nicotinamide for NAD+ synthesis , raising intracellular NAD+ and activating SIRT1 (Sirtuin 1) pathways tied to mitochondrial biogenesis and fat oxidation [3]

It counteracts both dopamine deficiency and excess, receptor blockade and overstimulation, neuronal destruction and vesicle depletion, all at the same dose range

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This gut-healing mechanism is also worth understanding in the broader context of how gut health drives systemic inflammation and recovery