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Incretin analogues are an increasingly important class of drugs that provide substantial health benefits for people with obesity, with adverse effects limited primarily to gastrointestinal disturbances

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Experimental studies suggest that the peptide may influence the secretion of hormones, and a possible mechanism of action involving the modulation of adrenergic transmission has been proposed

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Structural visualization, image processing, and analysis of docking results were performed using PyMOL 2.5.2

doi: 10.3389/fphys.2026.1764165 Received 15 January 2026 Revised 29 December 2025 Accepted 19 January 2026 Published 09 February 2026 Volume 17 - 2026 Edited by Khosrow Kashfi, City University of New York, United States Reviewed by Jerzy Beltowski, Medical University of Lublin, Poland John Toscano, Johns Hopkins University, United States Updates Copyright 2026 Hirabayashi, Sasaki, Ohno, Takayama, Yamada and Hanaoka