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METH is known to alter metabolism extensively in the brain and periphery (Kim et al., 2019), potentially altering the pharmacodynamic and pharmacokinetic properties of any xenobiotic

10 mg, n = 1,606

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Consequently, experts have cautioned that the markedly higher Mn content of formulaespecially when prepared with Mn-rich watermay present an avoidable risk and warrants updated regulatory guidance (Mitchell et al., 2020