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To show that the sphincters failure is a part of the NSAIDs-toxicity, COX-1 and COX-2 inhibitors were used in dose regimens shown to induce gastric and small intestine ulcers, hepatotoxicity and encephalopathy (8-14)

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Type 2 diabetes is the most widespread worldwide

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High sugar consumption can lead to insulin resistance, impairing this conversion and potentially triggering hypothyroid symptoms despite treatment [16]