& Munro, V
Proposed revision of the esophageal cancer staging system to accommodate pathologic response (pP) following preoperative chemoradiation (CRT)
To identify the specific effects of ferroptosis on ESCs, primary ESCs were treated with several ferroptosis inducers, such as erastin (30 M), (1S,3R)-RSL3 (10 M), tert-butyl hydroperoxide solution (TBHP, 20 M), diluted cyst fluid (1:1 dilution with complete medium), and with inhibitor NAC (10 M) for 12 h
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The citric acid metabolites speak to mitochondrial health, with multiple markers inclusive of succinic and pyroglutamic acids pointing to glutathione status as a proxy for oxidative stress
Conclusion The interrelationship between PsD and its metabolic comorbidities namely obesity, T2DM, and CV disease is increasingly recognized as a critical determinant of patient outcomes requiring multidisciplinary management