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When glucose builds up in the bloodstream, it damages blood vessels and nerves throughout the body over time
Mutant p53-associated molecular mechanisms of ros regulation in cancer cells
TFEB (facteur de transcription EB), dans des conditions de stress lysosomal induit par des lipides athrognes tels que les LDL oxydes, dclenche la biogense lysosomale, notamment une expression accrue du gne LIPA (Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae 2014)
Drug interactions may also occur with monoamine oxidase inhibitors (MAOIs)
Its primary function involves the transport of fatty acids into the mitochondria, where they are oxidized to generate adenosine triphosphate (ATP), the bodys primary energy currency
For example, certain probiotics (e.g., lactobacilli ) reportedly activate the NRF2 pathway via metabolic routes [148], while some pathogens (e.g., Salmonella , Helicobacter pylori ) activate NOX1, upregulate ROS, and induce inflammation [149]
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