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GH IGF-1 downstream anabolic effects GH released by ipamorelin acts on hepatic GH receptors to induce IGF-1 production, which mediates most of the classically "anabolic" effects attributed to GH (protein synthesis, lipolysis, nitrogen retention, bone turnover)

A study by Ge et al

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Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia

doi: 10.1093/ndt/gfu287 96