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They do not have FDA approval, and it is illegal to introduce them into the body

So, for a 1000 mcg dose, you give 1 mL of the solution

Elevation in homocysteine is expected with cobalamin deficiency due to reduced methionine synthase activity even in the face of extreme cobalamin deficiency

16,17 It is unclear whether B12 is absorbed via the oral mucosa or in the small intestine with sublingual administration, and research into this question is scarce

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So those are the three mechanisms that Im aware of, at least, that BPC 157 does love it