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Statistical analysis All statistical analyses were carried out using GraphPad Prism (GraphPad Software)

If this "smoke" isn't cleared away, it can damage the mitochondria themselves, leading to decreased energy production

Future research can focus on using specific gene knockout/knock-in animal models and combining single-cell sequencing technology to clarify the spatiotemporal expression patterns and functional differences of p53 in different cell types (such as chondrocytes, synoviocytes, and osteoclasts) and different stages of OA

Injecting directly into muscle is usually more painful than injecting into the subcutaneous layer of fat below the skin

The results were visualized using Cytoscape software version 3.8.0 23

Functioning as a transcription factor, TP53 orchestrates intrinsic apoptosis by dampening the presence of survival proteins such as MCL1, MYC, and BCL2, while elevating pro-apoptotic genes such as BAX in colorectal cancer cells [121, 122]