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It is approximately 44,000 times more selective for DPP-8 dpp-4 than DPP-8 and about 10,000 times more selective than DPP-9, which results in Linagliptin primarily targeting DPP-4 with very little effect on DPP-8 or DPP-9 [30]

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[132] [133] Reinforcement disorders Addiction Addiction is a serious risk with heavy recreational amphetamine use, but is unlikely to occur from long-term medical use at therapeutic doses