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Eryptosis is stimulated by concentrations observed in the human body during occupational exposure or subacute poisoning

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Further studies revealed that USP22 regulated the ubiquitination and proteasomal degradation of silent information regulator 2-related protein 1 (Sirt1) in GMCs, modulated the AGEs/RAGE pathway, and stimulated the expression of FN and TGF-1, which accelerates the fibrosis process in diabetic kidneys[42]