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The American College of Cardiology, the American Heart Association, and the European Society of Hypertension have collaboratively formulated behavioral guidelines aimed at maintaining optimal blood pressure levels, with a particular emphasis on non-pharmacological strategies (135)

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Representative domains include: Gastrointestinal and hepatic models: Protection against ulcers, leaky gut, IBSlike symptoms, Crohntype inflammation, and toxic liver injury (e.g., CCl4, NSAID, and alcohol models), with improved mucosal healing and barrier integrity