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Additionally, discontinuing the medication without maintaining significant lifestyle changes can lead to weight regain, as the body may respond by increasing hunger hormones like ghrelin

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This function is mediated via the activation of the cAMP/PKA/CREB (cAMP-responsive element binding protein) and the transactivation of the EGF-R (epidermal growth factor receptor) leading to the activation of phosphatidylinositol-3 kinase (PI3K), protein kinase C(PKC), Akt-protein kinase B (AKT/PKB), extracellular regulated kinase (ERK1/2 or mitogen-activated protein kinase [MAPK]) signaling pathways and to the up-regulation of the expression of the cell cycle regulator cyclinD1 (Figure 3)

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Tirzepatide induced larger reductions in body weight vs GLP-1 RAs, ranging from 1.68 kg (95% CI 0.84, 2.52 [ I 2 0%]) with tirzepatide 5 mg to 7.16 kg (95% CI 4.86, 9.46 [ I 2 72%]) with tirzepatide 15 mg (Fig