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doi: 10.1016/s0168-8278(01)00037-x

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While it is not known if the impact on blood pressure was due to the medication or the participants weight loss, the lower blood pressure measures seen with tirzepatide rivaled what is seen for many hypertension medications. The current research was a planned sub-study including 600 of the participants from the SURMOUNT-1 weight loss study to determine if there was an effect on blood pressure

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Animal studies show protection against myocardial infarction damage, arrhythmia prevention, and a unique ability to activate collateral blood vessel pathways