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Protein shakes designed for GLP-1 users have become increasingly popular as a practical way to meet protein targets when appetite is suppressed

Kiss (2022)

Furthermore, experimental evidence has shown that GDF15 may influence pain modulation by reducing nociceptive neuron excitability through peripheral mechanisms involving Nav1.8 sodium channel suppression and modulation of protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) signaling pathways 26,27,28,29