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LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the KruskalWallis test used alone can achieve a lower false-negative rate compared to LEfSe 38

The three repeat-dose studies it did identify were of an unspecified form of CJC-1295 DAC and are published as conference abstracts only not as full papers

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The mTORC1 phosphorylates lipin 1 to increase the activity of SREBP1 or activates SREBP1 through an S6K1-dependent mechanism, thus participating in lipid synthesis [43, 44]