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and taking injections in the evening before rest

Commonly noted side effects include fluid retention, numbness in the hands or feet, and increased feelings of tiredness

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Using the technique of a Markov-based stochastic mathematical process to measure inter-movement intervals and characterize the periodicity of PLMS, 51 researchers have demonstrated that subjects with RLS-related PLMS (and likely PLMD) have less inter-movement interval variability (with intervals clustering between 24 and 28 seconds) than is seen in PLMS due to other conditions (such as narcolepsy and ADHD)