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Individuals 60 years and older have lower plasma GSH levels and increased oxidative stress (Samiec et al., 1998)

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coli , a plasmid-encoded GST attaches GSH to the epoxide ring of fosfomycin, opening the ring and rendering the drug inactive

10.1083/jcb.201007013 J

NAD+ levels decline with age, which can lead to weight gain, sluggishness, and metabolic resistance

Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch signaling In a series of studies in our and collaborating laboratories (although predominantly using colorectal cancer-originated tissue and cell lines), we have observed an intriguing inverse correlation between claudin-7 and claudin-1 expressions