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Subsequently, AGO2 recruits RNA polymerase-associated protein CTR9 homolog (part of the polymerase-associated factor 1 complex) and RNA helicase II (RHA) to form the RNA-induced transcriptional activation (RITA) complex

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It also modifies the immunosuppressive TME, promoting immune activation, suggesting that enhancing chimeric antigen receptor cell function may represent a potential strategy for glioblastoma therapy (71)