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The in vivo degradation and tissue biocompatibility of the hydrogels were evaluated by subcutaneous implantation in Sprague Dawley (SD) rats

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Matrine inhibits IL-1-induced expression of matrix metalloproteinases by suppressing the activation of MAPK and NF-B in human chondrocytes in vitro

The second category was an adenovirus overexpression plasmid for the mouse Usp2 gene, with restriction enzyme sites AsisI/RsrII, a 3Flag tag fused at the C-terminus, and an Amp resistance gene (resistance concentration: 100 g/ml)

The sample size was determined pragmatically based on participant availability, and no formal power calculation was performed

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