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Body Composition: Individuals with different body compositions, particularly those with higher body fat percentages, may experience a slower onset of effects because semaglutide GLP-1 interacts differently in the body

Davies MJ, Aronne LJ, Caterson ID, Thomsen AB, Jacobsen PB, Marso SP, et al

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If the molecules directly interact with the mutant sites, these two enzymes may exhibit resistance-causing mutations that affect the drug activity [254, 255]

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