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The targeting of signaling partners to GLP-1rs is likely mediated by in some areas by A-kinase anchoring protein (AKAP) scaffolding proteins, which have been shown to target PKA to GLP-1r(Lester et al., 1997)

Curr Pharm Biotechnol 11(5):434443 Dunlap LE, Andrews AM, Olson DE (2018) Dark classics in chemical neuroscience: 3,4-methylenedioxymethamphetamine (MDMA)

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Beyond their glucose-lowering properties, GLP-1 RAs have gained significant attention as a therapeutic option for individuals with type 2 diabetes and obesity due to their appetite-suppressing effects (Fig