There is a small amount of confusion on this topic because of how glutathione is used in high-dose clinical settings
For patients dealing with photodamage or hyperpigmentation, GHK-Cu reduces both by addressing the oxidative stress and inflammatory processes that drive them
This is why many turn to supplements to bridge the gap, and Cymbiotikas Healthy Aging Supplements collection is a natural place to explore that category more broadly
However, in case of the ASCT2, studies showed that cysteine is actually a competitive inhibitor and not a substrate for ASCT2 ( Figure 1 via Multidrug Resistance Protein 1 exporter (MRP1), is cleaved extracellularly by -Glutamyl transferase (GGT) forming -Glutamyl-X substrate and Cysteinyl-Glycine
Interestingly, all three cytokines elevated in SZ patients in Table 1 (IL-1, IL-6, and IL-8) are regulated via the NF-B pathway
Magnusson 1992