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GIP, which is secreted by K cells of the duodenum and the proximal part of the small intestine, is the principal incretin hormone in humans, providing most of the incretin effect (21)

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will necessarily result in weight gain due to insulin resistance that develops as a result of this type of diet

CHO cells expressing human GLP-1R were dispensed at 1 10 5 cells/mL in assay buffer (Hanks Balanced Salt Solution containing 0.1% BSA (Sigma-Aldrich) and 0.5 mM IBMX (Sigma-Aldrich)) in 384-well assay plates (5 L per well) before adding dilutions of tested compounds prepared by a manual tip-based method

Int J Pharmacogn Chinese Med

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