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RCT SCALE Study - Liraglutide vs Placebo for Weight Loss in Overweight Nondiabetic Adults, NEJM (2015) [PubMed abstract] The SCALE study enrolled 3731 overweight adults who did not have diabetes Main inclusion criteria BMI 30

It also helps regulate blood sugar, reduces constipation, and supports healthy gut bacteria

Other Double Agonists and Triple Agonist Beyond tirzepatide, pharmaceutical companies have developed additional dual receptor agonists targeting GLP-1 and glucagon (GCG) as well as triple receptor agonists

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Weight regain happens without a long-term plan Losing weight is one thing

"But, if they stop these medications, weight regain occurs in the vast majority of patients, and the metabolic benefits are lost