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However, the potential for delaying or preventing the progression of T2DM in patients treated with GIP and GLP-1 remains uncertain, as there is currently no definitive evidence from human studies demonstrating that enhanced incretin activity directly affects -cell mass or alters the progressive loss of insulin secretory capacity in humans

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Approved as cimetidine in 1977, the arrival of the new drug radically reduced the need for surgical intervention for duodenal and gastric ulcers (Black

3, July 2016, pp

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