While human clinical trials are still needed, the preclinical evidence is compelling
The tolerable upper intake level (UL) is 400mcg per day our dose is well within this safe range
Robinson AM, Williamson DH
Using the CheEA3 transcription factor (TF) enrichment analysis tool, we observed that transcription of 7 ( Ppara, Tgfbr2, Ndrg1, Mt2, Htatip2, Akr1b7, Fbp1 ) of the 9 up-regulated DEGs genes (called group 1 TSGs) could result in TF binding sites (BS) for liver X receptors (LXRs) (GEO-GSE35262, ChIP-Seq)
The GPxi strains of Hypsizygus marmoreus showed defects in mycelial growth and fruiting body development
Studies demonstrate that B-complex vitamin supplementation lowers homocysteine levels while enhancing ovulatory function and insulin sensitivity which indicates these nutrients might serve as potential therapeutic agents for PCOS ( Figure 3 )