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The cornerstone protocol identifies Methotrexate as the absolute gold standard, with an initial dosage of seven point five to ten milligrams per week, to be titrated up to twenty-five milligrams, always combined with folic acid supplementation to reduce toxicity

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Other identified triggers for mania were brain stimulation, including ECT/transcranial magnetic stimulation (TMS), energy drinks, acetyl-l-carnitine, St

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