Metabolic and digestive response to food ingestion in a binge-feeding lizard, the Gila monster (Heloderma suspectum)
Once-daily oral administration of ID110521156 in diabetic monkeys resulted in reduced plasma glucose levels, increased insulin secretion, decreased food intake, and weight loss
Targets GLP-1, GIP, and glucagon receptors for advanced metabolic support
SCFAs activate free fatty acid receptors FFAR2 and FFAR3 on L-cells, thereby stimulating GLP-1 secretion
Connecting those anecdotal accounts with the fact that there are GLP-1 receptors in the brain in regions that modulate reward processing, and therefore might affect cravings, Al-Aly and his collaborators investigated whether GLP-1s could treat all substance use disorders
When covered, GLP-1s are typically subject to utilization controls such as prior authorization, which can further limit access