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Losing 20 pounds means roughly 25 fewer pounds of force on that tissue with every step

fragilis increased the level of Glycoursodeoxycholic acid in the gut, then led to the activation of intestinal FXR signaling

This is annoying but not usually damaging

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L-arginine supplementation can lower blood pressure and should be used cautiously in individuals taking antihypertensive medications or those with existing hypotension

Together, these findings strongly suggest: Statin therapy disrupts the gut microbiome by depleting key bacteria involved in bile acid metabolism