We chose the GK rats since they spontaneously develop T2DM without obesity and mild renal damage, and the DPP-4 inhibitor sitagliptin is one of the drugs commonly used for the treatment of T2DM in CKD patients due to its safety profile
Liang, Y., et al
In turn, this prevents polyubiquitination and proteasomal degradation of Nrf2 protein stabilizing its levels ( Besides, SFN can potentially alleviate/break the vicious cycle of oxidative stress and gut dysbiosis shown in Figure 4
When starting both medications together, or adding one to an established regimen of the other, patients should: Take sertraline with food to minimise gastric irritation Follow the gradual dose titration schedule for Mounjaro as prescribed Stay well hydrated, especially if experiencing vomiting or diarrhoea Report persistent or severe gastrointestinal symptoms to their GP Risk of dehydration and kidney function : If significant vomiting or diarrhoea occurs, it's important to maintain adequate hydration
If you're not seeing progress by week 8, PlexusDx recommends discussing dose adjustment or lifestyle modifications with your healthcare provider to optimize your protocol
Semegalutide is FDA-approved for the treatment of diabetes, obesity-related health conditions, and chronic weight management (specifically Wegovy) and is safely prescribed off-label for weight loss
