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In AD animal models, M1-polarized microglia frequently co-exist with iron accumulation, indicating a synergistic interaction between inflammatory activation and disrupted iron metabolism in driving neurotoxicity (Mendoza and Scharff, 2017)

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Results Ms4a15 expression specifically blocks ferroptosis Ms4a15 was identified in a CRISPR activation screen protecting against ferroptosis [32]

The peptide is absorbed directly into the capillaries and enters systemic circulation