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[17] [18] Supply constraints have affected NHS availability

If approved, the pharmaceutical version will likely be priced at a premium to tirzepatide, which itself is more expensive than semaglutide

As always, the side effects vary between treatments and individuals

However, retatrutide is still in Phase 3 trials and does not yet have FDA approval

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GLP-1 Receptor Activation Metabolic Regulation GLP2 activates GLP-1 receptors with lower potency than endogenous GLP-1 but demonstrates biased signaling properties: Preferential cAMP pathway activation over beta-arrestin recruitment, which may enhance insulin secretory responses Suppression of inappropriately elevated glucagon secretion during hyperglycemia Reduced GLP-1 receptor internalization compared to native GLP-1, potentially extending signaling duration Contribution to glucose-dependent insulin secretion complementary to GIP receptor effects Research in isolated pancreatic islets demonstrated that GLP2s insulinotropic actions depend on GIP receptor presence, with the biased GLP-1 receptor signaling providing synergistic enhancement