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Although the electron density at the distal end of the octanoyl group was not visible in the three structures, it undoubtedly resides within Cavity II

Candidate transporters and receptors involved in colistin uptake across the brush-border membrane of the proximal tubular cells are the Glycosylphosphatidylinositol (GPI)-anchored protein megalin 13 , the human peptide transporter 2 (PEPT2, SLC15A2 ) and the carnitine/organic cation transporter 2 (OCTN2, SLC22A5 ) 14,15

However, cautious use of this stack is advised, as individual responses and potential side effects can vary

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease