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Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males

Scopolamine hydrobromide (S-1875) from Sigma-Aldrich was used to induce cognitive deficits in behavioral studies

Apr 2011b;76(5):455-463

The mechanism involves decreased expression of mitofusin 2 (Mfn2), leading to increased mitochondrial fission and reactive oxygen species (ROS) production, ultimately resulting in cardiomyocyte apoptosis [118]