The causes of GLP-1 agonist side effects include: GLP-1 side effects are more noticeable at certain times: Most patients who take GLP-1 drugs tolerate them well
Some lean mass loss can occur during any major weight-loss program including GLP-1 treatment but recent research suggests the muscle loss may not be as severe as experts once feared
Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications with specific licensed indications in the UK
Last reviewed: June 5, 2026 Last updated: June 5, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Rangaswami J, Bhalla V, de Boer IH, et al
It can increase the thermogenesis and utilization of triacylglycerol-derived fatty acids and glucose in brown adipocytes and reduce the lipid content through the central GLP-1R agonists signaling pathway, such as central AMP-activated protein kinase or sirtuin-1 (SIRT1), also known as NAD-dependent deacetylase SIRT1 (3639)
