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The total cycle time was 1.05 s

Structural understanding of GLP-1 GLP-1R interaction, especially GLP-1 interactions with the extracellular domain (ECD) of GLP-1R, is vital for optimizing GLP-1-based therapeutics and designing next-generation GLP-1R agonists with improved pharmacological profiles, as GLP-1R ECD mediates the initial step in ligand-receptor binding, downstream GLP-1R activation and transmembrane sigal transduction [2831]

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doi: 10.1038/s41392-024-02039-0 151 ParkE-JParkY-JLeeSJLeeKYoonC