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We were motivated to do this study purely because of our experience, Joseph F

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Barrier disruption leads to antigen leakage, activating antigen-presenting cells and T/B lymphocytes to initiate inflammation

Additionally, the endothelial glycocalyx, a cellular microstructure of proteoglycans and glycoproteins on the endothelial cell surface, is disrupted in COVID-19 patients (9698)

This weekly interval was chosen during clinical trials to optimize glycemic control and weight management outcomes