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J Clin Pathol 1994

Pyruvate dehydrogenase deficiency

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Patients should not discontinue semaglutide without consulting their healthcare provider unless instructed to do so for safety reasons

It was speculated that this increase in DR risk with semaglutide OW in SUSTAIN 6 was due to the large and rapid reduction in HbA 1c levels, as observed with other existing therapies [58]